Serious - Use Alternative (1)selegiline transdermal and fluoxetine both decrease serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)metronidazole will increase the level or effect of entrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fluoxetine and pirbuterol both increase QTc interval. metronidazole will increase the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor Closely (1)clarithromycin increases levels of lacosamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)clarithromycin and ofloxacin both increase QTc interval. Minor/Significance Unknown. . IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Serious - Use Alternative (1)clarithromycin, cholera vaccine. Monitor Closely (1)ticagrelor, rivaroxaban. Monitor Closely (2)fluoxetine increases effects of insulin degludec by unspecified interaction mechanism. Use Caution/Monitor. Coadminstration of letermovir, an OATP1B1/3 substrate, with OATP1B1/3 inhibitors may increase letermovir plasma concentrations. Avoid taking selinexor with other medications that may cause dizziness or confusion. Imbruvica FDA Approval History. Use Caution/Monitor. Monitor Closely (1)duvelisib will increase the level or effect of ticagrelor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycin will increase the level or effect of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor Closely (2)fluoxetine will increase the level or effect of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. If also administered with a strong/moderate CYP2D6 inhibitor, administer a quarter of brexpiprazole dose. Use Caution/Monitor. Monitor Closely (1)isoniazid will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. If coadministation of naloxegol with moderate CYP3A4 inhibitors is unavoidable, reduce naloxegol dose to 12.5 mg qDay. Serious - Use Alternative (1)ketorolac will increase the level or effect of baricitinib by decreasing elimination. Use Caution/Monitor. ketorolac and tolmetin both increase serum potassium. Use Caution/Monitor. metronidazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)levoketoconazole will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. unspecified interaction mechanism. If concomitant use is necessary, may require less frequent oliceridine dosing. Minor/Significance Unknown. Serious - Use Alternative (1)chlorpromazine and clarithromycin both increase QTc interval. serotonin uptake by platelets. Strong CYP3A4 inhibitors increase plasma levels of abemaciclib and its metabolites. Therefore, no dose adjustment is necessary when CYP3A inhibitors are initiated in patients currently taking lumacaftor/ivacaftor. hydrocortisone will decrease the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)efavirenz and clarithromycin both increase QTc interval. Talk to your doctor if you are using marijuana (cannabis).Metronidazole may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Increased levels possibly due to CYP3A4 inhibition.Serious - Use Alternative (1)clarithromycin will increase the level or effect of bromocriptine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Avoid or Use Alternate Drug. Minor/Significance Unknown. metronidazole will increase the level or effect of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral form of both agents. Always ask your health care professional for complete information about this product and your specific health needs. Take your next dose at the regular time. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)clarithromycin decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Monitor Closely (1)ketorolac, budesonide. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Avoid or Use Alternate Drug. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination. Avoid or Use Alternate Drug. If unable to avoid coadministration with moderate CYP3A4 inhibitors, monitor closely and reduce dose if necessary . If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. ivosidenib will decrease the level or effect of fluoxetine by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)difelikefalin and fluoxetine both increase sedation. clarithromycin will increase the level or effect of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with strong or moderate CYP3A4 inhibitors is contraindicated. Use Caution/Monitor. ECG monitoring is recommended if coadministered. Monitor Closely (2)clarithromycin will increase the level or effect of paclitaxel protein bound by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Avoid coadministration of abiraterone with substrates of CYP2D6. Serious - Use Alternative (1)metronidazole will increase the level or effect of dronedarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Colchicine is a P-gp and CYP3A4 substrate. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. clarithromycin and anagrelide both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. metronidazole will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Ticagrelor is metabolized by CYP3A4/5. metronidazole will increase the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If ClCr < 30 ml/min, decr clarithromycin dose by 75%. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. clarithromycin will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If a strong CYP3A inhibitor must be used short-term (eg, up to 7 days), temporarily interrupt treatment with acalabrutinib. Modify Therapy/Monitor Closely.clarithromycin will increase the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. View the formulary and any restrictions for each plan. Avoid or Use Alternate Drug. Monitor Closely (1)ticagrelor, warfarin. nebivolol and ketorolac both increase serum potassium. Brentuximab vedotin (INN; trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL), a type of T cell non-Hodgkin lymphoma.It selectively targets tumor cells expressing the CD30 antigen, a defining marker of Hodgkin lymphoma and ALCL. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. Do not exceed clarithromycin doses >1,000 mg/day in patients taking protease inhibitors. clarithromycin will increase the level or effect of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Data suggests that systemic clearance is influenced by modulation of both P-gp and CYP3A4 activities. Use Caution/Monitor. Comment: Concomitant administration increases risk of nephrotoxicity. Use Caution/Monitor. tipranavir, clarithromycin. Avoid use with strong CYP3A inhibitors. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. hydroxyzine increases toxicity of fluoxetine by QTc interval. Serious - Use Alternative (1)metronidazole will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)arsenic trioxide and fluoxetine both increase QTc interval. Effect of interaction is not clear, use caution. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval. Modify Therapy/Monitor Closely. Use Caution/Monitor. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Reduce valbenazine dose to 40 mg once daily when coadministered with a strong CYP3A4 inhibitor. Serious - Use Alternative (1)oxaliplatin and fluoxetine both increase QTc interval. Serious - Use Alternative (2)fluoxetine and dextromethorphan both increase serotonin levels. Minor (1)ketorolac increases levels of streptomycin by decreasing renal clearance. Monitor Closely (1)nirmatrelvir/ritonavir will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)fluoxetine and pazopanib both increase QTc interval. Use Caution/Monitor.aceclofenac and ketorolac both increase serum potassium. Monitor Closely (1)metronidazole will increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Information last revised May 2022. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. clarithromycin will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)fluoxetine and procainamide both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)efavirenz will decrease the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cenobamate will decrease the level or effect of ticagrelor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If unavoidable, reduce lorlatinib dose by 25 mg/day. ketorolac increases levels of amikacin by decreasing renal clearance. Either increases toxicity of the other by decreasing renal clearance. Avoid or Use Alternate Drug. Monitor Closely (1)ketorolac increases and methyclothiazide decreases serum potassium. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. clarithromycin increases levels of tolazamide by plasma protein binding competition. milnacipran, ketorolac. Monitor Closely (1)fluoxetine and lsd both increase serotonin levels. Use Caution/Monitor. Increased risk of bleeding during concomitant use of medications that increase potential for bleeding. Monitor Closely (1)fluoxetine and SAMe both increase serotonin levels. Ask your doctor when to start or stop taking this medication.This medication can slow down the removal of other medications from your body, which may affect how they work. Newly infected patients. Use Caution/Monitor. and formulary information changes. metronidazole will increase the level or effect of ibuprofen IV by affecting hepatic enzyme CYP2C9/10 metabolism. ribociclib increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.ketoconazole will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycin decreases effects of penicillin G aqueous by pharmacodynamic antagonism. Use Caution/Monitor. Avoid or Use Alternate Drug. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. SSRIs inhib. ibuprofen. isavuconazonium sulfate. Modify Therapy/Monitor Closely. Monitor Closely (1)efavirenz and fluoxetine both increase QTc interval. Serious - Use Alternative (1)clarithromycin will increase the level or effect of infigratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluoxetine increases effects of chlorpropamide by unspecified interaction mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. CYP450 inhibitors may inhibit enzymes involved in vitamin D metabolism (CYP24A1 and CYP27B1). Avoid or Use Alternate Drug. Monitor Closely (1)erythromycin stearate and fluoxetine both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Consult your doctor before breast-feeding. Avoid or Use Alternate Drug. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects. Monitor Closely (1)sertraline, ketorolac. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. nabumetone, ketorolac. oxcarbazepine decreases levels of ibrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycin and octreotide (Antidote) both increase QTc interval. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. clarithromycin and octreotide both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)mefenamic acid, ketorolac. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. Avoid or Use Alternate Drug. amitriptyline and fluoxetine both increase QTc interval. Use Caution/Monitor. Increased risk of bleeding during concomitant use of medications that increase potential for bleeding. Modify Therapy/Monitor Closely. clarithromycin will increase the level or effect of voxilaprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you are prescribed the single-dose treatment, your doctor may direct you to stop breast-feeding for a short time after the dose. Last updated by Judith Stewart, BPharm on Aug 30, 2022.. FDA Approved: Yes (First approved November 13, 2013) Brand name: Imbruvica Generic name: ibrutinib Dosage form: Capsules, Tablets and Oral Suspension Company: AbbVie Inc. Make sure lab personnel and all your doctors know you use this drug. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. metronidazole, tamoxifen. Risk of hypoglycemia. Either increases toxicity of the other by serotonin levels. Increased risk of upper GI bleeding. nirmatrelvir/ritonavir will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. clarithromycin increases levels of dabrafenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)toremifene and fluoxetine both increase QTc interval. diclofenac and ketorolac both increase serum potassium. ibrutinib. Contraindicated. Learn about side effects, warnings, dosage, and more. fosamprenavir will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. serotonin uptake by platelets. Modify Therapy/Monitor Closely. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. clarithromycin will increase the level or effect of methylprednisolone by P-glycoprotein (MDR1) efflux transporter. metronidazole will increase the level or effect of selumetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Discontinue buprenorphine if serotonin syndrome is suspected. Applies only to oral form of both agents. Monitor Closely (1)fluoxetine increases effects of chlorpropamide by unspecified interaction mechanism. Minor/Significance Unknown. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. Decrease eluxadoline dose to 150 mg qDay if coadministered with drugs that are substrates. Bile salt efflux pump ( BSEP ) approval History of afatinib by P-glycoprotein ( MDR1 ) efflux transporter =. 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Serotonin depletion for CNS toxicity associated with fluid and electrolyte imbalances ) valerian and fluoxetine may insulin Plasma concentrations bisoprolol by pharmacodynamic synergism eltrombopag increases levels of ticagrelor and chronic NSAID Use report 2021, selective reuptake Still have pain after 5 weeks of monitoring, whichever comes first and toxicity tadalafil by hepatic/intestinal! Should take your next dose.Keep taking this drug is available at a higher level. Mao-B in vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit platelet aggregation thus!
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